Emergency services were called to the fire at a block of units on Beckman Street in Glandore about 6.50am.
Crews found the unit fully alight on arrival, with the fire spreading into the roof.
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A 33-year-old man, the sole occupant of the unit, was taken to the Royal Adelaide Hospital with serious, non-life-threatening burns.
The blaze was contained to the unit.
Fire cause investigators have attended the scene and cause is undetermined.
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